Microdosing GLP-1s: A New Frontier in Weight Management

The weight loss landscape is evolving, and at the forefront is the practice of microdosing GLP-1 receptor agonists, such as Ozempic (semaglutide) and Zepbound (tirzepatide). Traditionally prescribed for type 2 diabetes and obesity, these medications are now being utilized in lower-than-standard doses to achieve weight maintenance, metabolic health improvements, and reduced side effects.  

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What Is Microdosing GLP-1s?

Microdosing involves administering GLP-1 medications at doses lower than the typical therapeutic levels. For instance, while the standard starting dose for Zepbound is 2.5 mg, some practitioners initiate treatment at 1.5 mg for women and 1.8 mg for men. This “low and slow” approach aims for gradual weight loss, targeting approximately 2 pounds per week, and is tailored to individual patient responses.

Dr. Craig Koniver, a family medicine physician in Charleston, South Carolina, reports that all 200 of his weight loss patients are on microdoses of GLP-1s. He emphasizes individualized dosing, with some patients maintaining their weight on even less frequent injections.  

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Why Are Patients and Doctors Turning to Microdosing?

    1.    Cost-Effectiveness: Brand-name GLP-1 medications can cost between $1,000 and $1,300 monthly without insurance coverage. Microdosing, often facilitated through compounded versions of these drugs, can reduce costs, starting as low as $200 per month.  

    2.    Reduced Side Effects: Lower doses are associated with fewer adverse effects, such as nausea, constipation, and fatigue, making the treatment more tolerable for many patients.  

    3.    Flexibility in Treatment: Microdosing allows for a more personalized approach, accommodating patients who may only need to lose a modest amount of weight or who are sensitive to higher doses.  

    4.    Maintenance and Metabolic Benefits: Some patients use microdosing as a maintenance strategy post-weight loss or to achieve metabolic health benefits beyond weight reduction.  

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The Role of Compounded Medications

Compounded GLP-1 medications have become a cornerstone of the microdosing trend, especially during periods of brand-name drug shortages. These versions are prepared by pharmacies and can offer customizable dosing options.

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Caution and Considerations

While microdosing presents promising advantages, medical professionals urge caution. The practice lacks extensive clinical research and standardized guidelines. Additionally, self-administering or adjusting doses without medical supervision can lead to unforeseen health risks. Patients are encouraged to consult healthcare providers to determine the most appropriate and safe treatment plan.  

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Final Thoughts

Microdosing GLP-1s represents an innovative approach to weight management, offering potential benefits in cost, side effect profile, and treatment flexibility. As with any medical intervention, it’s crucial to approach this strategy under professional guidance to ensure safety and efficacy.

For those exploring weight management options, discussing the possibility of microdosing GLP-1s with a healthcare provider could be a valuable step toward achieving health goals.

SOURCES:

https://www.medscape.com/viewarticle/some-patients-and-doctors-turn-microdosing-glp-1s-2025a10002y1

https://www.latimes.com/lifestyle/story/2024-11-05/microdosing-ozempic-weight-loss-drugs-diy-dosage

https://www.nytimes.com/2024/12/05/well/ozempic-microdose-weight-loss.html